[ FUND report Q2 2026 ]

UP Mid-Stage Global Health Fund

Series A funding in global health, bringing at least one cost-effective project to scale by 2029.

[ Lettet from the fund manager ]

Welcome to the latest Ultra Philanthropy Mid-Stage Global Health Fund report.

Jack Lewars

Fund Manager

This quarter we finished deploying our first fundraise, with a final grant to Family Empowerment Media towards a randomised controlled trial of their work - the kind of gold-standard evidence we want to fund more of, although health RCTs are expensive and we could only part-fund this one. If you backed that first raise, your money is now fully at work.

The highlight of the quarter was Lafiya securing a seven-figure GiveWell grant. I don't want to read too much into a single data point, but it goes some way to validating our thesis: an organisation we backed with money and hands-on support has won its first major grant from GiveWell, a funder operating at real scale. Other grantees have had smaller, discretionary GiveWell support but Lafiya is the first to win a new seven-figure grant, the first of our grantees to be funded by both the Gates Foundation and GiveWell, and has a real chance of reaching $10m a year in turnover, which is the scale to which the fund aims to take grantees.

Other grantees have made excellent progress as well. Healthy Futures has expanded into Angola, HealthLearn has doubled the health workers it trains, and Clear Solutions is now layering oral rehydration salts and zinc onto larger delivery programmes, including those of GiveWell top charities. The results are modelled estimates, but the direction is clear: this quarter our grantees estimate they prevented 63 child deaths from dehydration, 224 to 623 from malnutrition, and 365 maternal deaths - for very little money, and before any of them has reached scale.

We deployed $972k in grants in the last quarter, with a further $584k currently in process, and secured $227k in new contributions. Most of these grants were agreed in late 2025, with disbursement deferred at grantees’ request for operational reasons.

A particular highlight this quarter was a second grant to Clear Solutions, who distribute oral rehydration salts and zinc to prevent deaths from dehydration. In December, they alerted us to an urgent opportunity to reach communities in Chad with ORSZ in partnership with Malaria Consortium. This was, however, contingent on securing $700k of ORSZ by 31st December.

The fund moved quickly as the anchor donor and catalysed a further $456k from other donors, allowing this highly cost-effective programme to proceed and showcasing our ability to influence other grantmakers. This is precisely the kind of work we want to do more of: betting on our grantees in a way that unlocks further opportunities for them, and extends our impact beyond what we give directly.

Looking ahead, the fund has begun fundraising and assessing new projects for 2026. A recent survey of grantees and prospective grantees suggested room for more funding of $3.37m in 2026 and $19.26m in 2027 — a sharp increase year-on-year as organisations scale through the mid-stage.

Grant assessment is actively underway, and we expect to bring further opportunities to our investment committee before the end of May. We are also exploring whether to expand our research capacity to increase the speed and depth of our investigations.

Overall, we are delighted with the fund’s progress and the outstanding work of our grantees. Thank you for your generous support, which is enabling some of the most cost-effective global health work in the world to reach the scale it deserves. The need remains urgent, and we are glad to be meeting it together.

We think now is an unusually good time to support the fund. We believe significant philanthropy is coming from employees at frontier AI labs, plausibly in the billions, most likely in 2027. We are already talking to many of them: some have committed, but many have not yet decided.

Two things follow. We are fully deployed, with around $22m of opportunities we can't currently fund through 2027, and we model that every $1 we regrant this year lets our grantees absorb roughly $2 more next year (a central estimate with a wide range, model available on request). Based on conversations with prospective donors, we also expect them to weight a fund's track record and team, both of which are dependent on this year's donations. Accordingly, we are raising $3.6m for 2026 (and much for 2027). This comprises $3.2m in regranting capital, the amount we can deploy well this year, and $400k in operating costs to build the research team that finds these opportunities. The two are complements - operating costs carry a higher return but have a $400k ceiling, while we think we can move up to $22m in regranting capital by the end of 2027. To support the fund, please get in touch.

To everyone already backing the fund, thank you. I hope you are as proud as I am of what these organisations are achieving, and if you would like to talk about giving again, or for the first time, I would be glad to hear from you.

In our first year, we have funded an incredibly exciting portfolio of grantees. They deliver contraception to women in rural areas, empowering them with bodily autonomy. They deliver oral rehydration solution and zinc to caregivers, to prevent children dying from dehydration. They install solar-powered oxygen plants at hospitals to provide medical oxygen to critically ill patients. They test and treat the households of tuberculosis sufferers, to break the chain of transmission.

These are just a few of the amazing interventions the fund’s donors are supporting to scale.

In every case, we are privileged to work with amazing social entrepreneurs, who saw an injustice or failing in the world and thought “it doesn’t have to be like this”. We are so excited to see what they achieve and we believe they will bring outstanding interventions to national and international scale.

As well as who we fund, this report gives you an insight into how the fund runs. We operate on the leanest basis possible, stretching donor money as far as we can through streamlined operations. We also offer grantees access to a pool of incredible, subsidised consultants, to increase the impact of every donation, by offering technical assistance alongside funding.

Jack Lewars

Fund Manager

[ WHO WE FUND ]

Meet the grantees

Scroll to see more

  • Lafiya

    Upskills female health workers to provide family planning counseling and injectable contraceptives in remote areas.

  • Clear Solutions

    Conducts or advises on door-to-door distributions of oral rehydration solution and zinc, to treat dehydration.

  • Taimaka

    Trains and pays community health workers to do door-to-door malnutrition testing and treatment.

  • HealthLearn

    Offers mobile-friendly training for health workers, to help them implement effective, cheap interventions.

  • Healthy Futures

    Integrates syphilis testing and treatment into standard HIV screening for pregnant mothers.

  • Spiro

    Conducts household screening and treatment for tuberculosis in Pakistan.

  • HealthPort

    Builds solar-powered plants in Nigeria, to produce medical oxygen and supply it to hospitals for use in critical care.

  • Family Empowerment Media

    Mass media campaigns to improve take-up of modern contraception.

  • Lafiya

    Upskills female health workers to provide family planning counseling and injectable contraceptives in remote areas.

  • Clear Solutions

    Conducts or advises on door-to-door distributions of oral rehydration solution and zinc, to treat dehydration.

  • Taimaka

    Trains and pays community health workers to do door-to-door malnutrition testing and treatment.

  • HealthLearn

    Offers mobile-friendly training for health workers, to help them implement effective, cheap interventions.

  • Healthy Futures

    Integrates syphilis testing and treatment into standard HIV screening for pregnant mothers.

  • Spiro

    Conducts household screening and treatment for tuberculosis in Pakistan.

  • HealthPort

    Builds solar-powered plants in Nigeria, to produce medical oxygen and supply it to hospitals for use in critical care.

  • Family Empowerment Media

    Mass media campaigns to improve take-up of modern contraception.

  • Lafiya

    Upskills female health workers to provide family planning counseling and injectable contraceptives in remote areas.

  • Clear Solutions

    Conducts or advises on door-to-door distributions of oral rehydration solution and zinc, to treat dehydration.

  • Taimaka

    Trains and pays community health workers to do door-to-door malnutrition testing and treatment.

  • HealthLearn

    Offers mobile-friendly training for health workers, to help them implement effective, cheap interventions.

  • Healthy Futures

    Integrates syphilis testing and treatment into standard HIV screening for pregnant mothers.

  • Spiro

    Conducts household screening and treatment for tuberculosis in Pakistan.

  • HealthPort

    Builds solar-powered plants in Nigeria, to produce medical oxygen and supply it to hospitals for use in critical care.

  • Family Empowerment Media

    Mass media campaigns to improve take-up of modern contraception.

Lafiya

Upskills female health workers to provide family planning counseling and injectable contraceptives in remote areas.

Clear Solutions

Conducts or advises on door-to-door distributions of oral rehydration solution and zinc, to treat dehydration.

Taimaka

Trains and pays community health workers to do door-to-door malnutrition testing and treatment.

HealthLearn

Offers mobile-friendly training for health workers, to help them implement effective, cheap interventions.

Healthy Futures

Integrates syphilis testing and treatment into standard HIV screening for pregnant mothers.

Spiro

Conducts household screening and treatment for tuberculosis in Pakistan.

HealthPort

Builds solar-powered plants in Nigeria, to produce medical oxygen and supply it to hospitals for use in critical care.

Family Empowerment Media

Mass media campaigns to improve take-up of modern contraception.

[ Grant outputs and outcomes ]

2025-26 grant outputs and outcomes

HealthLearn

outputs

43,486

health workers completed the newborn care course in Nigeria

38,918

health workers completed the newborn care course in Zambia

outcomes

Outcome measurement not yet due

Taimaka

outputs

10,649

children suffering from acute malnutrition treated

outcomes

224 - 623

child deaths prevented during grant period (significant uncertainty modelling this figure)

Spiro

outputs

1,374

under 5 household contacts screened for TB

1,285

under 5 household contacts starting TB preventative therapy

17

active TB cases found (all ages and regions)

outcomes

Outcome measurement not yet due

Clear Solutions

outputs

121,551

children reached with ORSZ

outcomes

63

child deaths prevented

Lafiya

outputs

516

Lafiya Sisters trained during grant period

1,134,731

contraceptive doses distributed

580,513

family planning counselling sessions delivered to women

>65%

were first-time contraceptive users in Q2 2026

outcomes

71,069

unintended pregnancies averted in 2026

365

maternal deaths prevented in 2026

Healthy Futures

outputs

800,000

Maternal syphilis test kits included in Philippines government budget

outcomes

11

deaths prevented from miscarriages, stillbirths, and neonatal deaths

HealthPort

outputs

21m

litres of oxygen delivered across hospital partner network, up from 4m in 2025

₦23.8M

in quarterly revenue, 40% quarter-on-quarter growth

outcomes

Outcome measurement not yet due

HealthLearn

outputs

43,486

health workers completed the newborn care course in Nigeria

38,918

health workers completed the newborn care course in Zambia

outcomes

Outcome measurement not yet due

Taimaka

outputs

10,649

children suffering from acute malnutrition treated

outcomes

224 - 623

child deaths prevented during grant period (significant uncertainty modelling this figure)

Healthy Futures

outputs

800,000

Maternal syphilis test kits included in Philippines government budget

outcomes

11

deaths prevented from miscarriages, stillbirths, and neonatal deaths

Spiro

outputs

1,374

under 5 household contacts screened for TB

1,285

under 5 household contacts starting TB preventative therapy

17

active TB cases found (all ages and regions)

outcomes

Outcome measurement not yet due

Lafiya

outputs

516

Lafiya Sisters trained during grant period

1,134,731

contraceptive doses distributed

580,513

family planning counselling sessions delivered to women

>65%

were first-time contraceptive users in Q2 2026

outcomes

71,069

unintended pregnancies averted in 2026

365

maternal deaths prevented in 2026

HealthPort

outputs

21m

litres of oxygen delivered across hospital partner network, up from 4m in 2025

₦23.8M

in quarterly revenue, 40% quarter-on-quarter growth

outcomes

Outcome measurement not yet due

Clear Solutions

outputs

121,551

children reached with ORSZ

outcomes

63

child deaths prevented

HealthLearn

outputs

43,486

health workers completed the newborn care course in Nigeria

38,918

health workers completed the newborn care course in Zambia

outcomes

Outcome measurement not yet due

Lafiya

outputs

516

Lafiya Sisters trained during grant period

1,134,731

contraceptive doses distributed

580,513

family planning counselling sessions delivered to women

>65%

were first-time contraceptive users in Q2 2026

outcomes

71,069

unintended pregnancies averted in 2026

365

maternal deaths prevented in 2026

Taimaka

outputs

10,649

children suffering from acute malnutrition treated

outcomes

224 - 623

child deaths prevented during grant period (significant uncertainty modelling this figure)

Healthy Futures

outputs

800,000

Maternal syphilis test kits included in Philippines government budget

outcomes

11

deaths prevented from miscarriages, stillbirths, and neonatal deaths

Spiro

outputs

1,374

under 5 household contacts screened for TB

1,285

under 5 household contacts starting TB preventative therapy

17

active TB cases found (all ages and regions)

outcomes

Outcome measurement not yet due

HealthPort

outputs

21m

litres of oxygen delivered across hospital partner network, up from 4m in 2025

₦23.8M

in quarterly revenue, 40% quarter-on-quarter growth

outcomes

Outcome measurement not yet due

Clear Solutions

outputs

121,551

children reached with ORSZ

outcomes

63

child deaths prevented

[ WHERE THEY WORK ]

Grantee Map

Our grantees work in LMICs in Asia and Africa, where they can deliver maximum cost-effectiveness.

8 active grantees

11 countries

Map
LegendActive workExploring/Hiring/Advisory
Map
LegendActive workExploring/Hiring/Advisory
Map
LegendActive workExploring/Hiring/Advisory
Map
LegendActive workExploring/Hiring/Advisory

[ Grantee progress to scale ]

Grantee progress

Our grantees are at various stages on their journey to scale. Click a grantee to see their progress against their scaling objectives.

HEALTHLEARN
HEALTHPORT
TAIMAKA
LAFIYA
CLEAR SOLUTIONS
HEALTHY FUTURES
SPIRO
FAMILY EMPOWERMENT MEDIA
HealthLearn
Progress to Scale: 3/5
Objective 1: Offer the newborn care course in ≥3 countries.
On track: Newborn care course successfully launched in Zambia in Q4 2025. Approval secured for The Gambia and approval processes underway in Uganda.
Objective 2: Over 75,000 people to complete the newborn care course.
Completed: 80,257 people have completed the course in Nigeria and Zambia.
Objective 3: Design and budget a rigorous study of the newborn care course (e.g. RCT), or determine that it is not feasible.
Very Challenging: Pursuing a pre/post evaluation in The Gambia but unlikely to execute a more robust study during this grant. Still pursuing this grant outside the current grant period.
HEALTHLEARN
HEALTHPORT
TAIMAKA
LAFIYA
CLEAR SOLUTIONS
HEALTHY FUTURES
SPIRO
FAMILY EMPOWERMENT MEDIA
HealthLearn
Progress to Scale: 3/5
Objective 1: Offer the newborn care course in ≥3 countries.
On track: Newborn care course successfully launched in Zambia in Q4 2025. Approval secured for The Gambia and approval processes underway in Uganda.
Objective 2: Over 75,000 people to complete the newborn care course.
Completed: 80,257 people have completed the course in Nigeria and Zambia.
Objective 3: Design and budget a rigorous study of the newborn care course (e.g. RCT), or determine that it is not feasible.
Very Challenging: Pursuing a pre/post evaluation in The Gambia but unlikely to execute a more robust study during this grant. Still pursuing this grant outside the current grant period.
HEALTHLEARN
HEALTHPORT
TAIMAKA
LAFIYA
CLEAR SOLUTIONS
HEALTHY FUTURES
SPIRO
FAMILY EMPOWERMENT MEDIA
HealthLearn
Progress to Scale: 3/5
Objective 1: Offer the newborn care course in ≥3 countries.
On track: Newborn care course successfully launched in Zambia in Q4 2025. Approval secured for The Gambia and approval processes underway in Uganda.
Objective 2: Over 75,000 people to complete the newborn care course.
Completed: 80,257 people have completed the course in Nigeria and Zambia.
Objective 3: Design and budget a rigorous study of the newborn care course (e.g. RCT), or determine that it is not feasible.
Very Challenging: Pursuing a pre/post evaluation in The Gambia but unlikely to execute a more robust study during this grant. Still pursuing this grant outside the current grant period.
Ultra Philanthropy Mid-Stage Global Health Fund
Seed
HEALTHPORT
Early Mid-Stage
CLEAR SOLUTIONS
SPIRO
HEALTHLEARN
Healthy Futures
Mature Mid-Stage
TAIMAKA
LAFIYA
Family Empowerment Media
Scale
Cash Grants
Intensive Management Support
Expert Freelance Consultants
Valley of Death
Ultra Philanthropy Mid-Stage Global Health Fund
Seed
HEALTHPORT
Early Mid-Stage
CLEAR SOLUTIONS
SPIRO
HEALTHLEARN
Healthy Futures
Mature Mid-Stage
TAIMAKA
LAFIYA
Family Empowerment Media
Scale
Cash Grants
Intensive Management Support
Expert Freelance Consultants
Valley of Death

[ founders ]

Meet our founders

Dr Abubakar Umar

Co-Founder, Taimaka

Dr Aishat Adeniji

Co-Founder and CEO, HealthPort

Céline Kamsteeg

Co-Founder and Director of Growth, Lafiya

Habiba Banu

Co-Founder and Director of Operations and Research, Spiro

Dr Jun Young (Charlie) Jeong

Co-founder, Clear Solutions

Justin Graham

Co-Founder, Taimaka

Karl Keefer

Director of Technology, HealthLearn

Kenneth Scheffler

Co-Founder, Family Empowerment Media

Dr Keyur Doolabh

Co-Founder, Healthy Futures

Klau Chmielowska

Co-Founder and Co-Executive Director, Lafiya

Lia Boldt

Co-Founder, Family Empowerment Media

Marshall Thomas

Executive Director, HealthLearn

Martyn James

Co-founder, Clear Solutions

Nils Voelker

Co-Founder, Healthy Futures

[ contribution ]

Contribute to the fund

[ how we fund ]

Fund operations

The Mid-stage Global Health Fund operates on the leanest basis possible, allowing us to focus on adding value beyond our grantmaking. Donors benefit from pooling their funds, allowing them to support a wider range of projects than they could alone, and diversifying the risk of supporting early-stage projects.

"Support from the Ultra Philanthropy Mid-stage Global Health Fund has allowed our small team to focus more energy on improving our program, building our operations, testing pathways to quickly scale up, and improving our monitoring and evaluation. Founders already have so much to do – it’s hugely catalytic to not worry about fundraising in the short term.”
"Support from the Ultra Philanthropy Mid-stage Global Health Fund has allowed our small team to focus more energy on improving our program, building our operations, testing pathways to quickly scale up, and improving our monitoring and evaluation. Founders already have so much to do – it’s hugely catalytic to not worry about fundraising in the short term.”

Marshall Thomas, Co-Founder, HealthLearn

We aim to fund a range of projects, to give us the greatest chance of achieving our fund goal, which is to bring at least one cost-effective health intervention to scale by 2029. However, we also aim to offer transformative funding and support to organizations, helping them to focus on scaling and programme improvements, head of fundraising:

Beyond financial support, the Fund offers intensive management and technical assistance to grantees, to maximize their chances of success and make donor contributions go further. To enable this, the Fund has recruited a high-quality Investment Committee and a number of expert consultants, who are available to grantees at a rate subsidised by the Fund.

The Fund holds and disburses grants from a US DAF with Vanguard Charitable and a UK-US DAF with National Philanthropic Trust, two highly respected providers holding over $270bn in assets. These accounts can receive contributions of cash, stocks and crypto tax-deductibly in the US and the UK. Tax-deductible options may be available in other jurisdictions on request.

Our fundraising strategy concentrates on major donors who want the convenience of a pooled fund and are sufficiently impact-focussed to prefer a thesis-driven fund to establishing a costly private foundation or philanthropy. The minimum contribution to the Fund is therefore US$100k/year (including any matching funds), and donors can contribute for 1-3 years at a time. Donors are subject to Know Your Customer checks via Vanguard Charitable and NPT, which will involve providing passport information. Donors may opt in to share their identities with other donors, partners or grantees.

The Fund is currently free, as we have raised an operating costs grant for 2026-2027. We may reintroduce fees in the future to sustain the sourcing, vetting, monitoring, reporting and ongoing technical support to grantees.

Funds are invested in Vanguard Charitable’s Income and money market funds in the US, and split between UBS MSCI ACWI and cash in the UK, owing to the short-term disbursement schedule. All proceeds are added to the fund balance. The Vanguard Income fund comprises 80% bonds and 20% stock index funds. These funds in total encompass ~$86trn in assets.

[ Fundraising, grants and expenses ]

Fund financials

Donations & Grants Cashflow (USD)
DonationsGrants
$ 3.35m$ 2.47m$ 1.0m$ 2.0m$ 3.0m$ 4.0mNov 2025Dec 2025Jan 2026Feb 2026March 2026April 2026May 2026June 2026
Actual

This graph shows actual grant disbursements. However, many grantees ask the fund to hold grants for a period, to manage their cashflow and operations. As of 6/30/26, the fund has agreed but not yet disbursed a further $676k in grants. This means we have committed all of our available funds, minus a $100k cash buffer per Donor Advised Fund.

DonationsGrants
$ 3.35m$ 2.47m$ 1.0m$ 2.0m$ 3.0m$ 4.0mNov 2025Dec 2025Jan 2026Feb 2026March 2026April 2026May 2026June 2026
Actual

This graph shows actual grant disbursements. However, many grantees ask the fund to hold grants for a period, to manage their cashflow and operations. As of 6/30/26, the fund has agreed but not yet disbursed a further $676k in grants. This means we have committed all of our available funds, minus a $100k cash buffer per Donor Advised Fund.

How much did we fund our grantees?

We aim to fund as much of our grantees' funding gaps as possible.

Level

% of funding gap covered

% of funding gap covered

% of grants made at this level

% of grants made at this level

Marginal

0-20%

0%

Moderate

20-40%

35%

Significant

40-60%

18%

Very significant

60-80%

0%

All or almost all

>80%

46%

18 grants

agreed, to 9 organisations

We have raised $3.35m in our first 14 months, and agreed grants for $3.14m. We have so far signed grant agreements for 94% of funds within 3 months of receipt.

18 grants

agreed, to 9 organisations

We have raised $3.35m in our first 14 months, and agreed grants for $3.14m. We have so far signed grant agreements for 94% of funds within 3 months of receipt.

Grants by cause area
Access to modern contraception18%
Oral rehydration salts + zinc (ORSZ) distribution17%
HIV + syphilis testing for pregnant women15%
Training app for facility-based health workers14%
Door-to-door malnutrition testing & treatment12%
Distributing ORSZ via Malaria Consortium in Chad8%
RCT of mass media campaigns to improve take-up of modern contraception.6%
Installing oxygen plants at large hospitals and renting oxygen canisters to smaller hospitals5%
Household-based screening and preventative care for TB3%
Charity evaluation2%

[ Grant sourcing and vetting ]

Grant sourcing and vetting

The fund adds value by identifying promising, lesser-known interventions, which are either unknown or out of scope for existing funders. It doesn’t accept funding requests, instead sourcing opportunities through the Fund Manager’s network, including GiveWell, Ambitious Impact and Founders Pledge. These research teams share their research with Ultra Philanthropy and regularly share their insights on promising, underfunded cause areas. The fund aims to have a strong comparative advantage in sourcing dealflow.

We evaluate opportunities using the following process:

1

We conduct evaluations

2

To produce a full grant investigation (request access here), which covers:

3

All evaluated projects are ranked

4

Projects ‘above the bar’ are rated for the Fund’s specific target market and comparative advantage

1

We conduct evaluations

a) Based on existing materials

  • RCTs or other effectiveness studies (e.g. here)

  • Intervention / cause area effectiveness analysis (e.g. here)

  • External cost-effectiveness analyses of the project (e.g. here)

  • Internal cost-effectiveness analyses of the project (from the organisations)

b) Where needed, we build our own models (request access here)

c) We conduct information gathering calls with the leadership team

We evaluate opportunities using the following process:

1

We conduct evaluations

a) Based on existing materials

  • RCTs or other effectiveness studies (e.g. here)

  • Intervention / cause area effectiveness analysis (e.g. here)

  • External cost-effectiveness analyses of the project (e.g. here)

  • Internal cost-effectiveness analyses of the project (from the organisations)

b) Where needed, we build our own models (request access here)

c) We conduct information gathering calls with the leadership team

2

To produce a full grant investigation (request access here, which covers:

3

All evaluated projects are ranked

4

Projects ‘above the bar’ are rated for the Fund’s specific target market and comparative advantage

To date, our pipeline is

53

Considered

43

Shallow evaluation

21

Full evaluation

9

Organizations supported

[ Grant outputs and outcomes ]

Investment committee

The Investment Committee assists Jack, the Fund Manager, to make funding decisions.

Jack Lewars

Jack Lewars

Jack Lewars

Charlie Petty

Charlie Petty

Charlie Petty

Sasha Gallant

Sasha Gallant

Moshood O. Audu

Moshood O. Audu

Dr. Vevila Dornelles

Dr. Vevila Dornelles

Expert Consultants

Grantees can access technical assistance from our pool of expert consultants, with the grantee and the Fund splitting the cost.

Karen Levy

Fit for Purpose

Liz Jarman

Strategic Advisor & Executive Mentor

Olivia Kaye

M&E Specialist

Shreya K Pereira

M&E Specialist

Joshua Becker

Negotiation Specialist

Kevin Rosenberg

Strategy & Implementation

Will Jefferson

Communication, Feedback & Culture